太阳集团城娱8722提供——Atypical Neuroleptics in Plasma /Serum, on-line Analysis 质谱诊断方案
2022/3/4 17:29:25
太阳集团城娱8722提供——Atypical Neuroleptics in Plasma /Serum, on-line Analysis 质谱诊断方案
一、说明
The drugs olanzapine, clozapine, quetiapine, risperidone, and paliperidone (= 9-OH-risperidone) belong to the class of the so called "atypical" neuroleptics and are used for the treatment of schizophrenia. Co-medication, smoking, caffeine and food are factors that extensively influence their metabolism and thus lead to a high intraand interindividual variability of drug concentrations in blood. In order to avoid severe side effects by overdosing and to ensure an optimal therapeutic effect, therapeutic drug monitoring (TDM) is required. The RECIPE Complete Kit represents a fully automated, robust on-line SPE technique, a direct sample injection into the HPLC system.
二、产品优势
（1）Fully automated method
（2）On-line sample preparation
（3）100 % recovery
三、测试数据
Linearity: Olz/ D-Olz:
5/ 10-1000 μg/l
Clz / D-Clz:
6/5- 5000 μg/l
Qtp: 10 - 2000 μg/l
Plp, Rsp: 1 - 200 μg/l
Recovery: 100 %
LOD: 2 μg/l (Olz, Clz, D-Clz),
4 μg/I (D-Olz, Qtp)
0.4 μg/l (Plp, Rsp)
LLOQ: 5 μg/l (Olz), 6 μg/1 (Clz),
10 μg/I (D-Olz, Qtp),
4 μg/I (D-Clz)
1 μg/1 (Plp, Rsp)
Intraassay precision: 0.2 -2%
Interassay precision: 1- 6%
四、高效液相色谱参数
A: Determination of Olz, D-Olz, Clz, D-Clz, Qtp
B: Determination of Plp, Rsp
Isocratic pump 1
(SPE-buffer): flow rates: 0.5/ 1.0 ml/min
Isocratic pump 2
(mobile phase): flow rate: A: 1.3 ml/min
B: 1.0 ml/min
Switching valve: 6-port/3-channel
(order no. FK1102)
Injection volume: A: 250 μl, B: 750 μl
Injection interval: A: 22 min, B: 20 min
UV-detector: A: 254 nm, B: 280 nm
HPLC-thermostat: 30 °C
五、样品制备
六、订购信息
更多产品请咨询太阳集团城娱8722。
网址： www.xiyuan-bio.com
电话：021-58116080
手机：17717017426 陈经理 18019263206 陆经理
太阳集团城娱8722，您实验室试剂供应专家，欢迎咨询详谈。
一、说明
The drugs olanzapine, clozapine, quetiapine, risperidone, and paliperidone (= 9-OH-risperidone) belong to the class of the so called "atypical" neuroleptics and are used for the treatment of schizophrenia. Co-medication, smoking, caffeine and food are factors that extensively influence their metabolism and thus lead to a high intraand interindividual variability of drug concentrations in blood. In order to avoid severe side effects by overdosing and to ensure an optimal therapeutic effect, therapeutic drug monitoring (TDM) is required. The RECIPE Complete Kit represents a fully automated, robust on-line SPE technique, a direct sample injection into the HPLC system.
二、产品优势
（1）Fully automated method
（2）On-line sample preparation
（3）100 % recovery
三、测试数据
Linearity: Olz/ D-Olz:
5/ 10-1000 μg/l
Clz / D-Clz:
6/5- 5000 μg/l
Qtp: 10 - 2000 μg/l
Plp, Rsp: 1 - 200 μg/l
Recovery: 100 %
LOD: 2 μg/l (Olz, Clz, D-Clz),
4 μg/I (D-Olz, Qtp)
0.4 μg/l (Plp, Rsp)
LLOQ: 5 μg/l (Olz), 6 μg/1 (Clz),
10 μg/I (D-Olz, Qtp),
4 μg/I (D-Clz)
1 μg/1 (Plp, Rsp)
Intraassay precision: 0.2 -2%
Interassay precision: 1- 6%
四、高效液相色谱参数
A: Determination of Olz, D-Olz, Clz, D-Clz, Qtp
B: Determination of Plp, Rsp
Isocratic pump 1
(SPE-buffer): flow rates: 0.5/ 1.0 ml/min
Isocratic pump 2
(mobile phase): flow rate: A: 1.3 ml/min
B: 1.0 ml/min
Switching valve: 6-port/3-channel
(order no. FK1102)
Injection volume: A: 250 μl, B: 750 μl
Injection interval: A: 22 min, B: 20 min
UV-detector: A: 254 nm, B: 280 nm
HPLC-thermostat: 30 °C
五、样品制备
六、订购信息
更多产品请咨询太阳集团城娱8722。
网址： www.xiyuan-bio.com
电话：021-58116080
手机：17717017426 陈经理 18019263206 陆经理
太阳集团城娱8722，您实验室试剂供应专家，欢迎咨询详谈。
